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Target15-hydroxyprostaglandin dehydrogenase [NAD+]
LigandBDBM50266122
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1700506
Ki 0.060000±n/a nM
Citation Antczak, MIZhang, YWang, CDoran, JNaidoo, JVoruganti, SWilliams, NSMarkowitz, SDReady, JM Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair. J Med Chem60:3979-4001 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
15-hydroxyprostaglandin dehydrogenase [NAD+]
Name:15-hydroxyprostaglandin dehydrogenase [NAD+]
Synonyms:15-PGDH | Hpgd | Pgdh1 | Prostaglandin dehydrogenase 1 (15-PGDH)
Type:Enzyme
Mol. Mass.:28974.46
Organism:Homo sapiens (Human)
Description:P15428
Residue:266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50266122
NameBDBM50266122
Synonyms:CHEMBL4070789
TypeSmall organic molecule
Emp. Form.C19H21N5OS3
Mol. Mass.431.598
SMILESCCCC[S@@+]([O-])c1sc2nc(cc(-c3cnc(C)n3C)c2c1N)-c1nccs1 |r|
Structure
n/a