Target
Beta-secretase 1
Ligand
BDBM134293
Substrate
n/a
Meas. Tech.
ChEMBL_1712906 (CHEMBL4122955)
IC50
17±n/a nM
Citation
 Veenstra, SJRueeger, HVoegtle, MLueoend, RHolzer, PHurth, KTintelnot-Blomley, MFrederiksen, MRondeau, JMJacobson, LStaufenbiel, MNeumann, UMachauer, R Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorg Med Chem Lett 28:2195-2200 (2018) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM134293
Synonyms:
US8846658, 3
Type:
Small organic molecule
Emp. Form.:
C17H17BrN4O2
Mol. Mass.:
389.246
SMILES:
C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)c1 |r,c:6|
Structure:
Search PDB for entries with ligand similarity: