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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50008489
Substrate
n/a
Meas. Tech.
ChEBML_1717037
IC50
120±n/a nM
Citation
 Keri, RS; Chand, K; Budagumpi, S; Balappa Somappa, S; Patil, SA; Nagaraja, BM An overview of benzo[b]thiophene-based medicinal chemistry. Eur J Med Chem 138:1002-1033 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50008489
Synonyms:
(3-Benzo[b]thiophen-2-ylmethyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetic acid | CHEMBL342339
Type:
Small organic molecule
Emp. Form.:
C19H14N2O3S
Mol. Mass.:
350.391
SMILES:
OC(=O)Cc1nn(Cc2cc3ccccc3s2)c(=O)c2ccccc12
Structure:
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