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Target
Delta(24)-sterol reductase
Ligand
BDBM50278808
Substrate
n/a
Meas. Tech.
ChEBML_1719393
IC50
16900±n/a nM
Citation
 Müller, C; Hemmers, S; Bartl, N; Plodek, A; Körner, A; Mirakaj, V; Giera, M; Bracher, F New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem 140:305-320 (2017) [PubMed]  Article 
Target
Name:
Delta(24)-sterol reductase
Synonyms:
1.3.1.72 | 24-dehydrocholesterol reductase | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase | 3-beta-hydroxysterol Delta-24-reductase | DHC24_HUMAN | DHCR24 | Delta(24)-sterol reductase | Diminuto/dwarf1 homolog | KIAA0018 | Seladin-1
Type:
PROTEIN
Mol. Mass.:
60115.66
Organism:
Homo sapiens
Description:
ChEMBL_117046
Residue:
516
Sequence:
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
  
Inhibitor
Name:
BDBM50278808
Synonyms:
CHEMBL4170838
Type:
Small organic molecule
Emp. Form.:
C27H43NO3
Mol. Mass.:
429.6352
SMILES:
[H][C@@]1(CC[C@@]2([H])C3=CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(C)=O)[C@H](C)CNC(=O)CC |r,t:6|
Structure:
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