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TargetCatechol-O-methyltransferase
LigandBDBM50017852
Substrate/Competitorn/a
Meas. Tech.ChEBML_47065
IC50 12±n/a nM
Citation Bäckström, RHonkanen, EPippuri, AKairisalo, PPystynen, JHeinola, KNissinen, ELinden, IBMännistö, PTKaakkola, S Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J Med Chem32:841-6 (1989) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catechol-O-methyltransferase
Name:Catechol O-methyltransferase
Synonyms:n/a
Type:Enzyme
Mol. Mass.:29594.09
Organism:Rattus norvegicus (Rat)
Description:n/a
Residue:264
Sequence:
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNA
KPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMA
RLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDM
VFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSY
LEYMKVVDGLEKAIYQGPSSPDKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50017852
NameBDBM50017852
Synonyms:4-(3,4-Dihydroxy-5-nitro-phenyl)-3-methyl-but-3-en-2-one | CHEMBL167054
TypeSmall organic molecule
Emp. Form.C11H11NO5
Mol. Mass.237.2087
SMILESCC(=O)C(C)=Cc1cc(O)c(O)c(c1)[N+]([O-])=O |w:5.5|
Structure
n/a