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Target
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Ligand
BDBM50452635
Substrate
n/a
Meas. Tech.
ChEBML_78360
IC50
19±n/a nM
Citation
 Balasubramanian, N; Brown, PJ; Catt, JD; Han, WT; Parker, RA; Sit, SY; Wright, JJ A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase. J Med Chem 32:2038-41 (1989) [PubMed]  Article 
Target
Name:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Synonyms:
3-hydroxy-3-methylglutaryl coenzyme A synthase | HMCS1_RAT | HMG-CoA synthase | Hmgcs | Hmgcs1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Type:
PROTEIN
Mol. Mass.:
57428.09
Organism:
Rattus norvegicus
Description:
ChEMBL_78360
Residue:
520
Sequence:
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPSTNDHSLDEGVGLVHSNTATEHIPSPAKKVPRLPATSGEPESAVISNGEH
  
Inhibitor
Name:
BDBM50452635
Synonyms:
CHEMBL2367463
Type:
Small organic molecule
Emp. Form.:
C23H20F2N4O3
Mol. Mass.:
438.4267
SMILES:
[#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6@H]-1-[#6]-[#6@H](-[#8])-[#6]-[#6](=O)-[#8]1)=[#6](/c1ccc(F)cc1)-c1ccc(F)cc1
Structure:
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