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Target
17-beta-hydroxysteroid dehydrogenase 14
Ligand
BDBM50422422
Substrate
n/a
Meas. Tech.
ChEMBL_1739715 (CHEMBL4155465)
Ki
6.0±n/a nM
Citation
 Braun, F; Bertoletti, N; Möller, G; Adamski, J; Frotscher, M; Guragossian, N; Madeira Gírio, PA; Le Borgne, M; Ettouati, L; Falson, P; Müller, S; Vollmer, G; Heine, A; Klebe, G; Marchais-Oberwinkler, S Structure-based design and profiling of novel 17?-HSD14 inhibitors. Eur J Med Chem 155:61-76 (2018) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase 14
Synonyms:
17-beta-HSD 14 | 17-beta-hydroxysteroid dehydrogenase 14 | 17-beta-hydroxysteroid dehydrogenase DHRS10 | DHB14_HUMAN | DHRS10 | DHRS10 | Dehydrogenase/reductase SDR family member 10 | HSD17B14 | Retinal short-chain dehydrogenase/reductase retSDR3 | SDR3 | SDR47C1 | Short chain dehydrogenase/reductase family 47C member 1
Type:
PROTEIN
Mol. Mass.:
28316.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_114829
Residue:
270
Sequence:
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS
  
Inhibitor
Name:
BDBM50422422
Synonyms:
CHEMBL4164239
Type:
Small organic molecule
Emp. Form.:
C23H16FNO3
Mol. Mass.:
373.3764
SMILES:
Cc1cc(ccc1O)-c1ccc2ccc(nc2c1)C(=O)c1ccc(F)c(O)c1
Structure:
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