Reaction Details Report a problem with these data
Target
Solute carrier family 15 member 1
Ligand
BDBM50449807
Substrate
n/a
Meas. Tech.
ChEMBL_1740626 (CHEMBL4156376)
Ki
210000±n/a nM
Citation
 Foley, DW; Pathak, RB; Phillips, TR; Wilson, GL; Bailey, PD; Pieri, M; Senan, A; Meredith, D Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery. Eur J Med Chem 156:180-189 (2018) [PubMed]  Article 
Target
Name:
Solute carrier family 15 member 1
Synonyms:
Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | S15A1_RABIT | SLC15A1 | Solute carrier family 15 member 1
Type:
PROTEIN
Mol. Mass.:
78931.16
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_109684
Residue:
707
Sequence:
MGMSKSLSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFRNFIGWDDNLSTVIYHTFVALCYLTPILGALIADAWLGKFKTIVWLSIVYTIGQAVTSLSSVNELTDNNHDGTPDSLPVHVAVCMIGLLLIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMVRVQQCGIHVKQACYPLAFGIPAILMAVSLIVFIIGSGMYKKFKPQGNILSKVVKCICFAIKNRFRHRSKQFPKRAHWLDWAKEKYDERLIAQIKMVTRVLFLYIPLPMFWALFDQQGSRWTLQATTMSGRIGILEIQPDQMQTVNTILIIILVPIMDAVVYPLIAKCGLNFTSLKKMTIGMFLASMAFVAAAILQVEIDKTLPVFPKANEVQIKVLNVGSENMIISLPGQTVTLNQMSQTNEFMTFNEDTLTSINITSGSQVTMITPSLEAGQRHTLLVWAPNNYRVVNDGLTQKSDKGENGIRFVNTYSQPINVTMSGKVYEHIASYNASEYQFFTSGVKGFTVSSAGISEQCRRDFESPYLEFGSAYTYLITSQATGCPQVTEFEDIPPNTMNMAWQIPQYFLITSGEVVFSITGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQINKQWAEYILFAALLLVVCVIFAIMARFYTYVNPAEIEAQFEEDEKKKNPEKNDLYPSLAPVSQTQM
  
Inhibitor
Name:
BDBM50449807
Synonyms:
CHEMBL4168781
Type:
Small organic molecule
Emp. Form.:
C23H30N2O8S
Mol. Mass.:
494.558
SMILES:
COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(=O)OC[C@H](NC(=S)[C@H](C)N)C(O)=O |r|
Structure:
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