Target
Geranylgeranyl transferase type-1 subunit beta
Ligand
BDBM14459
Substrate
n/a
Meas. Tech.
ChEMBL_1750766 (CHEMBL4185526)
IC50
>1000±n/a nM
Citation
 Buuh, ZYLyu, ZWang, RE Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem 61:3239-3252 (2018) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-1 subunit beta
Synonyms:
GGTase-I-beta | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGTB1_RAT | Pggt1b | Type I protein geranyl-geranyltransferase subunit beta | geranylgeranyltransferase type-I
Type:
PROTEIN
Mol. Mass.:
42414.77
Organism:
Rattus norvegicus
Description:
ChEMBL_105008
Residue:
377
Sequence:
MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS
  
Inhibitor
Name:
BDBM14459
Synonyms:
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidin-yl]-2-oxo-ethyl]-1-piperidinecarboxamide | 4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide | CHEMBL298734 | Lonafarnib | SCH 66336 | Sarasar
Type:
Small organic molecule
Emp. Form.:
C27H31Br2ClN4O2
Mol. Mass.:
638.822
SMILES:
NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: