Reaction Details Report a problem with these data
Target
Lipopolysaccharide heptosyltransferase 1
Ligand
BDBM20876
Substrate
n/a
Meas. Tech.
ChEMBL_1753351 (CHEMBL4188111)
Ki
370000±n/a nM
Citation
 Nkosana, NK; Czyzyk, DJ; Siegel, ZS; Cote, JM; Taylor, EA Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A. Bioorg Med Chem Lett 28:594-600 (2018) [PubMed]  Article 
Target
Name:
Lipopolysaccharide heptosyltransferase 1
Synonyms:
2.-.-.- | Lipopolysaccharide heptosyltransferase 1 | RFAC_ECOLI | rfa-2 | rfaC | waaC | yibC
Type:
PROTEIN
Mol. Mass.:
35553.92
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117821
Residue:
319
Sequence:
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAENYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPRENLINLNSQAVLEKLSSL
  
Inhibitor
Name:
BDBM20876
Synonyms:
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol | [14C]alpha-methyl-D-glucopyranoside | alpha-methyl-D-glucopyranoside (AMG)
Type:
Carbonhydrate
Emp. Form.:
C7H14O6
Mol. Mass.:
194.1825
SMILES:
CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Structure:
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