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Target
Protein delta homolog 1
Ligand
BDBM50004205
Substrate
n/a
Meas. Tech.
ChEMBL_1764072 (CHEMBL4199319)
Ki
36±n/a nM
Citation
 Siu, M; Sengupta Ghosh, A; Lewcock, JW Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. J Med Chem 61:8078-8087 (2018) [PubMed]  Article 
Target
Name:
Protein delta homolog 1
Synonyms:
DLK | DLK-1 | DLK1 | DLK1_HUMAN | FA1 | Fetal antigen 1 | pG2
Type:
PROTEIN
Mol. Mass.:
41294.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1444684
Residue:
383
Sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
  
Inhibitor
Name:
BDBM50004205
Synonyms:
MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 | VX-68 | VX-680
Type:
Small organic molecule
Emp. Form.:
C23H28N8OS
Mol. Mass.:
464.586
SMILES:
CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Structure:
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