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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50033437
Substrate
n/a
Meas. Tech.
ChEMBL_1764841 (CHEMBL4200088)
IC50
>30000±n/a nM
Citation
 Baqi, Y; Pillaiyar, T; Abdelrahman, A; Kaufmann, O; Alshaibani, S; Rafehi, M; Ghasimi, S; Akkari, R; Ritter, K; Simon, K; Spinrath, A; Kostenis, E; Zhao, Q; Köse, M; Namasivayam, V; Müller, CE 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem 61:8136-8154 (2018) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50033437
Synonyms:
CHEMBL905 | MK 462 free base | N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine | N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine | N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine | RIZATRIPTAN | risatriptan
Type:
Small organic molecule
Emp. Form.:
C15H19N5
Mol. Mass.:
269.3449
SMILES:
CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12
Structure:
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