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Target
Renin-1
Ligand
BDBM50022866
Substrate
n/a
Meas. Tech.
ChEBML_196286
IC50
3200±n/a nM
Citation
 Sham, HL; Bolis, G; Stein, HH; Fesik, SW; Marcotte, PA; Plattner, JJ; Rempel, CA; Greer, J Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. J Med Chem 31:284-95 (1988) [PubMed]  Article 
Target
Name:
Renin-1
Synonyms:
Angiotensinogenase | Kidney renin | RENI1_MOUSE | Ren | Ren-1 | Ren1 | Renin | Renin-1
Type:
PROTEIN
Mol. Mass.:
44345.30
Organism:
Mus musculus
Description:
ChEMBL_685608
Residue:
402
Sequence:
MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
  
Inhibitor
Name:
BDBM50022866
Synonyms:
4-[1-{3-[1-[1-(1-amino-1-methylpropylcarboxamido)-2-methyl-(1S)-propylcarboxamido]-2-methyl-(1S)-propylcarboxamido]-2-hydroxy-5-methylhexylcarboxamido}-(1S)-ethylcarboxamido]-3-hydroxy-6-methylheptanoic acid | CHEMBL98582
Type:
Small organic molecule
Emp. Form.:
C34H64N6O9
Mol. Mass.:
700.9068
SMILES:
CCC(C)(N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NC(CC(C)C)C(O)CC(=O)N[C@@H](C)C(=O)NC(CC(C)C)C(O)CC(O)=O
Structure:
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