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Target
14-3-3 protein zeta/delta
Ligand
BDBM50462081
Substrate
n/a
Meas. Tech.
ChEMBL_1772681 (CHEMBL4229673)
Kd
370±n/a nM
Citation
 Stevers, LM; Sijbesma, E; Botta, M; MacKintosh, C; Obsil, T; Landrieu, I; Cau, Y; Wilson, AJ; Karawajczyk, A; Eickhoff, J; Davis, J; Hann, M; O'Mahony, G; Doveston, RG; Brunsveld, L; Ottmann, C Modulators of 14-3-3 Protein-Protein Interactions. J Med Chem 61:3755-3778 (2018) [PubMed]  Article 
Target
Name:
14-3-3 protein zeta/delta
Synonyms:
14-3-3 protein zeta/delta | 1433Z_HUMAN | KCIP-1 | Protein kinase C inhibitor protein 1 | YWHAZ
Type:
PROTEIN
Mol. Mass.:
27731.18
Organism:
Homo sapiens
Description:
ChEMBL_117504
Residue:
245
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
  
Inhibitor
Name:
BDBM50462081
Synonyms:
CHEMBL4243245
Type:
Small organic molecule
Emp. Form.:
C71H95N9O19S
Mol. Mass.:
1410.628
SMILES:
[H][C@@]12CC[C@H](COC)\C1=C\[C@@]1(C)C(CC([C@H](C)COC(C)=O)=C1[C@@H](O)[C@H](O)[C@@H]2C)OCc1ccccc1\C=N\OC[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNS(=O)(=O)c1cccc2c(cccc12)N(C)C)C(C)C |r,c:9,22|
Structure:
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