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Target
14-3-3 protein sigma
Ligand
BDBM50462083
Substrate
n/a
Meas. Tech.
ChEMBL_1772676 (CHEMBL4229668)
IC50
2600±n/a nM
Citation
 Stevers, LM; Sijbesma, E; Botta, M; MacKintosh, C; Obsil, T; Landrieu, I; Cau, Y; Wilson, AJ; Karawajczyk, A; Eickhoff, J; Davis, J; Hann, M; O'Mahony, G; Doveston, RG; Brunsveld, L; Ottmann, C Modulators of 14-3-3 Protein-Protein Interactions. J Med Chem 61:3755-3778 (2018) [PubMed]  Article 
Target
Name:
14-3-3 protein sigma
Synonyms:
1433S_HUMAN | Epithelial cell marker protein 1 | HME1 | SFN | Stratifin
Type:
PROTEIN
Mol. Mass.:
27757.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_775356
Residue:
248
Sequence:
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
  
Inhibitor
Name:
BDBM50462083
Synonyms:
CHEMBL4237531
Type:
Small organic molecule
Emp. Form.:
C21H23ClN3O9P
Mol. Mass.:
527.849
SMILES:
OP(O)(=O)OC[C@H](NC(=O)CNC(=O)c1ccc(CCl)cc1)C(=O)NCc1ccc2OCOc2c1 |r|
Structure:
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