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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50463322
Substrate
n/a
Meas. Tech.
ChEMBL_1778012 (CHEMBL4235004)
IC50
32380±n/a nM
Citation
 Thiele, NA; Kärkkäinen, J; Sloan, KB; Rautio, J; Huttunen, KM Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug. Bioorg Med Chem Lett 28:2856-2860 (2018) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50463322
Synonyms:
CHEMBL4242544
Type:
Small organic molecule
Emp. Form.:
C18H21ClN2O5
Mol. Mass.:
380.823
SMILES:
Cl.NC(Cc1cccc(c1)C(=O)NCCc1ccc(O)c(O)c1)C(O)=O
Structure:
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