Target
Histone deacetylase 1
Ligand
BDBM50463754
Substrate
n/a
Meas. Tech.
ChEMBL_1779290 (CHEMBL4236282)
Ki
0.280000±n/a nM
Citation
 Fournier, JFBhurruth-Alcor, YMusicki, BAubert, JAurelly, MBouix-Peter, CBouquet, KChantalat, LDelorme, MDrean, BDuvert, GFleury-Bregeot, NGauthier, BGrisendi, KHarris, CSHennequin, LFIsabet, TJoly, FLafitte, GMillois, CMorgentin, RPascau, JPiwnica, DRival, YSoulet, CThoreau, ÉTomas, L Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma. Bioorg Med Chem Lett 28:2985-2992 (2018) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50463754
Synonyms:
CHEMBL4240635
Type:
Small organic molecule
Emp. Form.:
C18H20F3N3O4
Mol. Mass.:
399.3643
SMILES:
CC(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Structure:
Search PDB for entries with ligand similarity: