Target
Intestinal-type alkaline phosphatase
Ligand
BDBM50464729
Substrate
n/a
Meas. Tech.
ChEMBL_1782194 (CHEMBL4253711)
IC50
240±n/a nM
Citation
 Jafari, BOspanov, MEjaz, SAYelibayeva, NKhan, SUAmjad, STSafarov, SAbilov, ZATurmukhanova, MZKalugin, SNEhlers, PLecka, JSévigny, JIqbal, JLanger, P 2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study. Eur J Med Chem 144:116-127 (2018) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM50464729
Synonyms:
CHEMBL4286917
Type:
Small organic molecule
Emp. Form.:
C13H5F6N3O2S
Mol. Mass.:
381.253
SMILES:
FC(F)(F)Oc1ccc(cc1)-c1nn2c(nc(cc2=O)C(F)(F)F)s1
Structure:
Search PDB for entries with ligand similarity: