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Target
Estradiol 17-beta-dehydrogenase 2
Ligand
BDBM50466002
Substrate
n/a
Meas. Tech.
ChEMBL_1789617 (CHEMBL4261351)
IC50
25±n/a nM
Citation
 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW Highly Potent 17?-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy. J Med Chem 61:10724-10738 (2018) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 2
Synonyms:
17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase
Type:
PROTEIN
Mol. Mass.:
41847.95
Organism:
Mus musculus
Description:
ChEMBL_104366
Residue:
381
Sequence:
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
  
Inhibitor
Name:
BDBM50466002
Synonyms:
CHEMBL4285743
Type:
Small organic molecule
Emp. Form.:
C24H13F6NO5S2
Mol. Mass.:
573.484
SMILES:
Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F
Structure:
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