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Target
Thymidine kinase
Ligand
BDBM50001103
Substrate
n/a
Meas. Tech.
ChEMBL_80696 (CHEMBL690791)
EC50
65800±n/a nM
Citation
 Holý, A; Günter, J; Dvoráková, H; Masojídková, M; Andrei, G; Snoeck, R; Balzarini, J; De Clercq, E Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J Med Chem 42:2064-86 (1999) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
2.7.1.21 | HHV3M2gp38 | HHV3_gp38 | HHV3gp38 | ORF36 | TK | Thymidine kinase
Type:
PROTEIN
Mol. Mass.:
37846.07
Organism:
Human herpesvirus 3
Description:
ChEMBL_14068
Residue:
341
Sequence:
MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGEDAICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNKEPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSHLSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQKSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCLRSMSPFVLSLEQTPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
  
Inhibitor
Name:
BDBM50001103
Synonyms:
(2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid | (PMEA)[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | 9-(2-(phosphonomethoxy)ethyl)adenine | 9-[(2-phosphonylmethoxy)ethyl]adenine | 9-[2-(phosphonomethoxy)ethyl]adenine | 9-[2-phosphonomethoxyethyl]adenine | 9-[3-(Phosphonomethoxy)ethyl]adenine (PMEA) | ADEFOVIR | CHEMBL484 | GS-0393 | US10071110, Compound Adefovir | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid(PMEA) | [2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid | {[2-(6-AMINO-9H-PURIN-9-YL)ETHOXY]METHYL}PHOSPHONIC ACID
Type:
Small organic molecule
Emp. Form.:
C8H12N5O4P
Mol. Mass.:
273.1857
SMILES:
Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Structure:
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