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Target
D(2) dopamine receptor
Ligand
BDBM50474410
Substrate
n/a
Meas. Tech.
ChEMBL_60540 (CHEMBL674348)
Ki
158±n/a nM
Citation
 Macdonald, GJ; Branch, CL; Hadley, MS; Johnson, CN; Nash, DJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Austin, NE; Jeffrey, P; Winborn, KY; Boyfield, I; Hagan, JJ; Middlemiss, DN; Reavill, C; Riley, GJ; Watson, JM; Wood, M; Parker, SG; Ashby, CR Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. J Med Chem 46:4952-64 (2003) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50474410
Synonyms:
CHEMBL2368620
Type:
Small organic molecule
Emp. Form.:
C29H36ClN3O3S
Mol. Mass.:
542.132
SMILES:
Cl.CS(=O)(=O)c1ccc2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)\C=C\c3ccccc3C#N)CCc2c1 |r,wU:14.12,wD:17.19,(21.76,-1.31,;-5.31,-2.17,;-4.24,-1.55,;-4.24,-2.79,;-5.31,-.94,;-2.91,-.78,;-2.91,.78,;-1.53,1.57,;,.78,;.8,1.73,;2.31,1.43,;3.02,,;4.56,.01,;5.33,1.34,;6.87,1.35,;7.63,2.69,;9.17,2.69,;9.95,1.36,;9.18,.02,;7.64,.02,;11.49,1.36,;12.26,.02,;11.64,-1.04,;13.8,.03,;14.57,-1.31,;16.11,-1.31,;16.88,.03,;18.42,.03,;19.19,-1.3,;18.43,-2.64,;16.89,-2.64,;16.12,-3.98,;15.5,-5.04,;2.29,-1.45,;.76,-1.7,;,-.78,;-1.53,-1.57,)|
Structure:
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