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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50474983
Substrate
n/a
Meas. Tech.
ChEMBL_304067 (CHEMBL839742)
Ki
1.3±n/a nM
Citation
 Atkinson, PJ; Bromidge, SM; Duxon, MS; Gaster, LM; Hadley, MS; Hammond, B; Johnson, CN; Middlemiss, DN; North, SE; Price, GW; Rami, HK; Riley, GJ; Scott, CM; Shaw, TE; Starr, KR; Stemp, G; Thewlis, KM; Thomas, DR; Thompson, M; Vong, AK; Watson, JM 3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity. Bioorg Med Chem Lett 15:737-41 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50474983
Synonyms:
CHEMBL183034
Type:
Small organic molecule
Emp. Form.:
C24H25N3O4
Mol. Mass.:
419.473
SMILES:
O=C1COc2ccc(OCC3CCN(CCOc4cccc5ncccc45)C3)cc2N1
Structure:
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