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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50475465
Substrate
n/a
Meas. Tech.
ChEMBL_321083 (CHEMBL872163)
Ki
0.251189±n/a nM
Citation
 Ahmed, M; Briggs, MA; Bromidge, SM; Buck, T; Campbell, L; Deeks, NJ; Garner, A; Gordon, L; Hamprecht, DW; Holland, V; Johnson, CN; Medhurst, AD; Mitchell, DJ; Moss, SF; Powles, J; Seal, JT; Stean, TO; Stemp, G; Thompson, M; Trail, B; Upton, N; Winborn, K; Witty, DR Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists. Bioorg Med Chem Lett 15:4867-71 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50475465
Synonyms:
CHEMBL196410
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O2S
Mol. Mass.:
375.872
SMILES:
Clc1cccc(c1)S(=O)(=O)n1ccc2c(cccc12)N1CCNCC1
Structure:
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