Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM22985
Substrate
n/a
Meas. Tech.
ChEMBL_1804550 (CHEMBL4303774)
Ki
4677±n/a nM
Citation
 Gordon, DEJang, GMBouhaddou, MXu, JObernier, KWhite, KMO'Meara, MJRezelj, VVGuo, JZSwaney, DLTummino, TAHüttenhain, RKaake, RMRichards, ALTutuncuoglu, BFoussard, HBatra, JHaas, KModak, MKim, MHaas, PPolacco, BJBraberg, HFabius, JMEckhardt, MSoucheray, MBennett, MJCakir, MMcGregor, MJLi, QMeyer, BRoesch, FVallet, TMac Kain, AMiorin, LMoreno, ENaing, ZZCZhou, YPeng, SShi, YZhang, ZShen, WKirby, ITMelnyk, JEChorba, JSLou, KDai, SABarrio-Hernandez, IMemon, DHernandez-Armenta, CLyu, JMathy, CJPPerica, TPilla, KBGanesan, SJSaltzberg, DJRakesh, RLiu, XRosenthal, SBCalviello, LVenkataramanan, SLiboy-Lugo, JLin, YHuang, XPLiu, YWankowicz, SABohn, MSafari, MUgur, FSKoh, CSavar, NSTran, QDShengjuler, DFletcher, SJO'Neal, MCCai, YChang, JCJBroadhurst, DJKlippsten, SSharp, PPWenzell, NAKuzuoglu-Ozturk, DWang, HYTrenker, RYoung, JMCavero, DAHiatt, JRoth, TLRathore, USubramanian, ANoack, JHubert, MStroud, RMFrankel, ADRosenberg, OSVerba, KAAgard, DAOtt, MEmerman, MJura, Nvon Zastrow, MVerdin, EAshworth, ASchwartz, Od'Enfert, CMukherjee, SJacobson, MMalik, HSFujimori, DGIdeker, TCraik, CSFloor, SNFraser, JSGross, JDSali, ARoth, BLRuggero, DTaunton, JKortemme, TBeltrao, PVignuzzi, MGarcía-Sastre, AShokat, KMShoichet, BKKrogan, NJ A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583:459-468 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM22985
Synonyms:
Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
Type:
Antimalarial
Emp. Form.:
C18H26ClN3
Mol. Mass.:
319.872
SMILES:
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: