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Target
Histone-lysine N-methyltransferase E(z)
Ligand
BDBM50315537
Substrate
n/a
Meas. Tech.
ChEMBL_650292 (CHEMBL1224950)
IC50
>90000±n/a nM
Citation
 Greiner, D; Bonaldi, T; Eskeland, R; Roemer, E; Imhof, A Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:143-5 (2005) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase E(z)
Synonyms:
E(z) | EZ_DROME | KMT6 | Lysine N-methyltransferase 6 | Protein enhancer of zeste
Type:
PROTEIN
Mol. Mass.:
86931.57
Organism:
Drosophila melanogaster
Description:
ChEMBL_861239
Residue:
760
Sequence:
MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV
  
Inhibitor
Name:
BDBM50315537
Synonyms:
CHEMBL1089316 | chaetocin
Type:
Small organic molecule
Emp. Form.:
C30H28N6O6S4
Mol. Mass.:
696.84
SMILES:
CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21|
Structure:
Search PDB for entries with ligand similarity: