Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50033062
Substrate
n/a
Meas. Tech.
ChEMBL_197234 (CHEMBL801380)
EC50
530±n/a nM
Citation
 Dawson, MI; Jong, L; Hobbs, PD; Cameron, JF; Chao, WR; Pfahl, M; Lee, MO; Shroot, B; Pfahl, M Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. J Med Chem 38:3368-83 (1995) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50878.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197216
Residue:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50033062
Synonyms:
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-benzoic acid | CHEMBL116859
Type:
Small organic molecule
Emp. Form.:
C21H24O3
Mol. Mass.:
324.4135
SMILES:
CC1(C)CCC(C)(C)c2cc(Oc3ccc(cc3)C(O)=O)ccc12
Structure:
Search PDB for entries with ligand similarity: