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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50036920
Substrate
n/a
Meas. Tech.
ChEMBL_861 (CHEMBL615917)
IC50
0.021±n/a nM
Citation
 Norman, MH; Rigdon, GC; Navas, F; Cooper, BR Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents. J Med Chem 37:2552-63 (1994) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50036920
Synonyms:
2-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one | CHEMBL83625
Type:
Small organic molecule
Emp. Form.:
C23H31N5OS
Mol. Mass.:
425.59
SMILES:
O=C1C2CCCCC2C=NN1CCCCN1CCN(CC1)c1nsc2ccccc12 |c:9|
Structure:
Search PDB for entries with ligand similarity: