Reaction Details
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Acyl-protein thioesterase 1
Ligand
BDBM50496628
Substrate
n/a
Meas. Tech.
ChEMBL_1300908 (CHEMBL3135195)
IC50
27±n/a nM
Citation
Davda, D; Martin, BR Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation. Medchemcomm 5:268-276 (2014) [PubMed] Article More Info.:
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
APT-1 | APT1 | Acyl-protein thioesterase 1 (APT1 WT) | LPL-I | LPL1 | LYPA1_HUMAN | LYPLA1 | LysoPLA I | Lysophospholipase 1 | Lysophospholipase I | hAPT1
Type:
Protein
Mol. Mass.:
24670.33
Organism:
Homo sapiens (Human)
Description:
O75608
Residue:
230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
Inhibitor
Name:
BDBM50496628
Synonyms:
CHEMBL3133034
Type:
Small organic molecule
Emp. Form.:
C50H81N5O7S2
Mol. Mass.:
928.337
SMILES:
[H][C@@]12[#6]-[#6@@H](-[#6]-[#7]1-[#6](=O)-c1cc(ccc1-[#7](-[#6]-[#6]-[#7])-[#6]2=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#16]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](=O)-[#8]-[#6])-[#7]S(=O)(=O)[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6] |r|
Structure:
