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Target
1-deoxy-D-xylulose-5-phosphate synthase
Ligand
BDBM50496736
Substrate
n/a
Meas. Tech.
ChEMBL_1331618 (CHEMBL3225361)
Ki
6700±n/a nM
Citation
 Smith, JM; Vierling, RJ; Meyers, CF Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates(). Medchemcomm 3:65-67 (2012) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose-5-phosphate synthase
Synonyms:
1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase)) | DXS_ECOLI | dxs | yajP
Type:
Protein
Mol. Mass.:
67617.17
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
n/a
Residue:
620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
  
Inhibitor
Name:
BDBM50496736
Synonyms:
CHEMBL3220784
Type:
Small organic molecule
Emp. Form.:
C4H8LiO4P
Mol. Mass.:
158.019
SMILES:
[Li;v0+].[#6]-[#6]-[#8]P([#8-])(=O)[#6](-[#6])=O
Structure:
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