Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ligand
BDBM50497029
Substrate
n/a
Meas. Tech.
ChEMBL_1335026 (CHEMBL3239457)
Kd
5900±n/a nM
Citation
 Yun, MKHoagland, DKumar, GWaddell, MBRock, COLee, REWhite, SW The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg Med Chem 22:2157-65 (2014) [PubMed]  Article 
Target
Name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase | HPPK | HPPK_ECOLI | JW0138 | PPPK | folK
Type:
PROTEIN
Mol. Mass.:
18075.55
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_108237
Residue:
159
Sequence:
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
  
Inhibitor
Name:
BDBM50497029
Synonyms:
CHEMBL3233208
Type:
Small organic molecule
Emp. Form.:
C14H13N5O2S
Mol. Mass.:
315.35
SMILES:
Cc1cccc(c1)C(=O)CSc1nc2nc(N)[nH]c(=O)c2[nH]1
Structure:
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