Reaction Details Report a problem with these data
Target
Cytochrome b-245 heavy chain
Ligand
BDBM50497272
Substrate
n/a
Meas. Tech.
ChEMBL_1390859 (CHEMBL3391327)
IC50
12000±n/a nM
Citation
 Cifuentes-Pagano, E; Saha, J; Csányi, G; Ghouleh, IA; Sahoo, S; Rodríguez, A; Wipf, P; Pagano, PJ; Skoda, EM Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm 4:1085-1092 (2013) [PubMed]  Article 
Target
Name:
Cytochrome b-245 heavy chain
Synonyms:
CGD91-phox | CY24B_HUMAN | CYBB | Cytochrome b(558) subunit beta | Cytochrome b-245, beta polypeptide [Homo sapiens] | Cytochrome b558 subunit beta | Heme-binding membrane glycoprotein gp91phox | NADPH oxidase 2 | NADPH oxidase 2 (NOX2) | NOX2 | Neutrophil cytochrome b 91 kDa polypeptide | Superoxide-generating NADPH oxidase heavy chain subunit | gp91-1 | gp91-phox | p22 phagocyte B-cytochrome
Type:
Enzyme
Mol. Mass.:
65355.82
Organism:
Homo sapiens (Human)
Description:
P04839
Residue:
570
Sequence:
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
  
Inhibitor
Name:
BDBM50497272
Synonyms:
CHEMBL3347543
Type:
Small organic molecule
Emp. Form.:
C22H27BrN2O
Mol. Mass.:
415.367
SMILES:
[H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1Cc1cc(C)on1)c1c(Br)cccc21 |r,TLB:22:21:3.2:13.8,9:8:3.2:27.21,THB:14:13:3.2:27.21|
Structure:
Search PDB for entries with ligand similarity: