Reaction Details Report a problem with these data
Target
Anionic trypsin
Ligand
BDBM50046343
Substrate
n/a
Meas. Tech.
ChEBML_212173
EC50
26±n/a nM
Citation
 Balasubramanian, N; St Laurent, DR; Federici, ME; Meanwell, NA; Wright, JJ; Schumacher, WA; Seiler, SM Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series. J Med Chem 36:300-3 (1993) [PubMed]  Article 
Target
Name:
Anionic trypsin
Synonyms:
Anionic trypsin | TRY2_BOVIN | Trypsin II
Type:
PROTEIN
Mol. Mass.:
26281.39
Organism:
Bos taurus
Description:
ChEMBL_212177
Residue:
247
Sequence:
MHPLLILAFVGAAVAFPSDDDDKIVGGYTCAENSVPYQVSLNAGYHFCGGSLINDQWVVSAAHCYQYHIQVRLGEYNIDVLEGGEQFIDASKIIRHPKYSSWTLDNDILLIKLSTPAVINARVSTLLLPSACASAGTECLISGWGNTLSSGVNYPDLLQCLVAPLLSHADCEASYPGQITNNMICAGFLEGGKDSCQGDSGGPVACNGQLQGIVSWGYGCAQKGKPGVYTKVCNYVDWIQETIAANS
  
Inhibitor
Name:
BDBM50046343
Synonyms:
1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide | CHEMBL319227
Type:
Small organic molecule
Emp. Form.:
C21H29N5O4
Mol. Mass.:
415.4861
SMILES:
NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C(=O)CCc1ccccc1)C=O
Structure:
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