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Target
Integrase
Ligand
BDBM50479096
Substrate
n/a
Meas. Tech.
ChEMBL_1499863 (CHEMBL3583195)
IC50
33±n/a nM
Citation
 Pescatori, L; Métifiot, M; Chung, S; Masoaka, T; Cuzzucoli Crucitti, G; Messore, A; Pupo, G; Madia, VN; Saccoliti, F; Scipione, L; Tortorella, S; Di Leva, FS; Cosconati, S; Marinelli, L; Novellino, E; Le Grice, SF; Pommier, Y; Marchand, C; Costi, R; Di Santo, R N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase. J Med Chem 58:4610-23 (2015) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50479096
Synonyms:
CHEMBL498713
Type:
Small organic molecule
Emp. Form.:
C20H12Cl2FNO5
Mol. Mass.:
436.217
SMILES:
OC(=O)C(\O)=C\C(=O)c1cn(Cc2ccc(F)cc2)c2cc(Cl)c(Cl)cc2c1=O
Structure:
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