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TargetHydroxycarboxylic acid receptor 2
LigandBDBM23515
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1502259
EC50 47±n/a nM
Citation van Veldhoven, JPLiu, RThee, SAWouters, YVerhoork, SJMooiman, CLouvel, JIJzerman, AP Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists. Bioorg Med Chem23:4013-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM23515
NameBDBM23515
Synonyms:CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-niacin | pyridine-3-carboxylic acid | wampocap
TypeSmall organic molecule
Emp. Form.C6H5NO2
Mol. Mass.123.1094
SMILESOC(=O)c1cccnc1
Structure
n/a