Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50036918
Substrate
n/a
Meas. Tech.
ChEMBL_845 (CHEMBL615901)
IC50
0.19±n/a nM
Citation
 Norman, MH; Minick, DJ; Rigdon, GC Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives. J Med Chem 39:149-57 (1996) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50036918
Synonyms:
2-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-isoindole-1,3-dione | CHEMBL290937
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2S
Mol. Mass.:
420.527
SMILES:
O=C1N(CCCCN2CCN(CC2)c2nsc3ccccc23)C(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: