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Target
Acid ceramidase
Ligand
BDBM367214
Substrate
n/a
Meas. Tech.
ChEMBL_1542475 (CHEMBL3743922)
IC50
14±n/a nM
Citation
 Bach, A; Pizzirani, D; Realini, N; Vozella, V; Russo, D; Penna, I; Melzig, L; Scarpelli, R; Piomelli, D Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. J Med Chem 58:9258-72 (2015) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM367214
Synonyms:
6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 38
Type:
Small organic molecule
Emp. Form.:
C25H21ClN2O4
Mol. Mass.:
448.898
SMILES:
Clc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Structure:
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