Target
Sterol O-acyltransferase 1
Ligand
BDBM50051474
Substrate
n/a
Meas. Tech.
ChEMBL_28798 (CHEMBL641708)
IC50
13±n/a nM
Citation
 O'Brien, PMSliskovic, DRPicard, JALee, HTPurchase, CFRoth, BDWhite, ADAnderson, MMueller, SBBocan, TBousley, RHamelehle, KLHoman, RLee, PKrause, BRReindel, JFStanfield, RLTurluck, D Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. J Med Chem 39:2354-66 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50051474
Synonyms:
CHEMBL78038 | N-(4,6-Dimethoxy-pyrimidin-5-yl)-2-(2-dodecyl-2H-tetrazol-5-yl)-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C27H39N7O3
Mol. Mass.:
509.6437
SMILES:
CCCCCCCCCCCCn1nnc(n1)C(C(=O)Nc1c(OC)ncnc1OC)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: