Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50054281
Substrate
n/a
Meas. Tech.
ChEMBL_28664 (CHEMBL649062)
IC50
13±n/a nM
Citation
 White, ADCreswell, MWChucholowski, AWBlankley, CJWilson, MWBousley, RFEssenburg, ADHamelehle, KLKrause, BRStanfield, RLDominick, MANeub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem 39:4382-95 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50054281
Synonyms:
1-(2,6-Diisopropyl-phenyl)-3-(3-tridecyl-isoxazol-5-yl)-urea | CHEMBL136276
Type:
Small organic molecule
Emp. Form.:
C29H47N3O2
Mol. Mass.:
469.7024
SMILES:
CCCCCCCCCCCCCc1cc(NC(=O)Nc2c(cccc2C(C)C)C(C)C)on1
Structure:
Search PDB for entries with ligand similarity: