Target
Acidic mammalian chitinase
Ligand
BDBM50504036
Substrate
n/a
Meas. Tech.
ChEMBL_1813251 (CHEMBL4312825)
IC50
35±n/a nM
Citation
 Mazur, MDymek, BKoralewski, RSklepkiewicz, POlejniczak, SMazurkiewicz, MPiotrowicz, MSalamon, MJ?drzejczak, KZagozdzon, ACzestkowski, WMatyszewski, KBorek, BBartoszewicz, APluta, ERymaszewska, AMozga, WStefaniak, FDobrza?ski, PDzwonek, KGolab, JGolebiowski, AOlczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem 62:7126-7145 (2019) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | CHIA_MOUSE | Chia | Chia1 | YNL
Type:
PROTEIN
Mol. Mass.:
51991.60
Organism:
Mus musculus
Description:
ChEMBL_828636
Residue:
473
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
  
Inhibitor
Name:
BDBM50504036
Synonyms:
CHEMBL4472377
Type:
Small organic molecule
Emp. Form.:
C19H28ClN7O
Mol. Mass.:
405.925
SMILES:
CC(=O)NCCN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1
Structure:
Search PDB for entries with ligand similarity: