Target
Acidic mammalian chitinase
Ligand
BDBM50504014
Substrate
n/a
Meas. Tech.
ChEMBL_1813253 (CHEMBL4312827)
IC50
50±n/a nM
Citation
 Mazur, MDymek, BKoralewski, RSklepkiewicz, POlejniczak, SMazurkiewicz, MPiotrowicz, MSalamon, MJ?drzejczak, KZagozdzon, ACzestkowski, WMatyszewski, KBorek, BBartoszewicz, APluta, ERymaszewska, AMozga, WStefaniak, FDobrza?ski, PDzwonek, KGolab, JGolebiowski, AOlczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem 62:7126-7145 (2019) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50504014
Synonyms:
CHEMBL4547227
Type:
Small organic molecule
Emp. Form.:
C18H25ClN6O
Mol. Mass.:
376.884
SMILES:
Nc1n[nH]c(n1)N1CCC(CC1)N1C[C@H](O)C[C@@H]1Cc1ccc(Cl)cc1 |r|
Structure:
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