Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50055379
Substrate
n/a
Meas. Tech.
ChEMBL_156189 (CHEMBL761440)
IC50
6±n/a nM
Citation
 Draheim, SE; Bach, NJ; Dillard, RD; Berry, DR; Carlson, DG; Chirgadze, NY; Clawson, DK; Hartley, LW; Johnson, LM; Jones, ND; McKinney, ER; Mihelich, ED; Olkowski, JL; Schevitz, RW; Smith, AC; Snyder, DW; Sommers, CD; Wery, JP Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem 39:5159-75 (1997) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50055379
Synonyms:
(3-Aminooxalyl-1-biphenyl-2-ylmethyl-2-cyclopropyl-1H-indol-4-yloxy)-acetic acid | CHEMBL347957
Type:
Small organic molecule
Emp. Form.:
C28H24N2O5
Mol. Mass.:
468.5006
SMILES:
NC(=O)C(=O)c1c(C2CC2)n(Cc2ccccc2-c2ccccc2)c2cccc(OCC(O)=O)c12
Structure:
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