Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50505050
Substrate
n/a
Meas. Tech.
ChEMBL_1817339 (CHEMBL4316999)
Ki
0.010000±n/a nM
Citation
 Wang, XBlackaby, WAllen, VChan, GKYChang, JHChiang, PCDične, CDrummond, JDo, SFan, EHarstad, EBHodges, AHu, HJia, WKofie, WKolesnikov, ALyssikatos, JPLy, JMatteucci, MMoffat, JGMunugalavadla, VMurray, JNash, DNoland, CLDel Rosario, GRoss, LRouse, CSharpe, ASlaga, DSun, MTsui, VWallweber, HYu, SFEbens, AJ Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem 62:2140-2153 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50505050
Synonyms:
CHEMBL4439756
Type:
Small organic molecule
Emp. Form.:
C20H22F3N7OS
Mol. Mass.:
465.495
SMILES:
Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC(N)CC(F)C1
Structure:
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