Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50505059
Substrate
n/a
Meas. Tech.
ChEMBL_1817339 (CHEMBL4316999)
Ki
0.007000±n/a nM
Citation
 Wang, XBlackaby, WAllen, VChan, GKYChang, JHChiang, PCDične, CDrummond, JDo, SFan, EHarstad, EBHodges, AHu, HJia, WKofie, WKolesnikov, ALyssikatos, JPLy, JMatteucci, MMoffat, JGMunugalavadla, VMurray, JNash, DNoland, CLDel Rosario, GRoss, LRouse, CSharpe, ASlaga, DSun, MTsui, VWallweber, HYu, SFEbens, AJ Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem 62:2140-2153 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50505059
Synonyms:
CHEMBL4459538
Type:
Small organic molecule
Emp. Form.:
C21H25F2N7O2S
Mol. Mass.:
477.531
SMILES:
CO[C@H]1C[C@H](N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r|
Structure:
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