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Target
Cathepsin D
Ligand
BDBM50506532
Substrate
n/a
Meas. Tech.
ChEMBL_1826027 (CHEMBL4325791)
IC50
8.2±n/a nM
Citation
 Hou?tecká, R; Hadzima, M; Fanfrlík, J; Brynda, J; Pallová, L; Hánová, I; Mertlíková-Kaiserová, H; Lep?ík, M; Horn, M; Smr?ina, M; Majer, P; Mare?, M Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis. J Med Chem 63:1576-1596 (2020) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50506532
Synonyms:
CHEMBL4561907
Type:
Small organic molecule
Emp. Form.:
C31H49N3O4
Mol. Mass.:
527.7385
SMILES:
O[C@H]1CC(=O)N[C@@H](C2CCCCC2)C(=O)NCCCCCCCCCCCC(=O)N[C@H]1Cc1ccccc1 |r|
Structure:
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