Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Ligand
BDBM50508544
Substrate
n/a
Meas. Tech.
ChEMBL_1833217 (CHEMBL4333225)
IC50
33±n/a nM
Citation
 Boutard, NBia?as, ASabiniarz, AGuzik, PBanaszak, KBiela, ABie?, MBuda, ABugaj, BCieluch, ECierpich, ADudek, ?Eggenweiler, HMFogt, JGaik, MGondela, AJakubiec, KJurzak, MKitli?ska, AKowalczyk, PKujawa, MKwieci?ska, KLe?, MLindemann, RMaciuszek, MMikulski, MNiedziejko, PObara, APawlik, HRzymski, TSieprawska-Lupa, MSowi?ska, MSzeremeta-Spisak, JStachowicz, ATomczyk, MMWiklik, KW?oszczak, ?Ziemia?ska, SZar?bski, ABrzózka, KNowak, MFabritius, CH Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Bioorg Med Chem Lett 29:646-653 (2019) [PubMed]  Article 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Synonyms:
6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | F263_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2
Type:
Enzyme
Mol. Mass.:
59620.59
Organism:
Homo sapiens (Human)
Description:
Q16875
Residue:
520
Sequence:
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
  
Inhibitor
Name:
BDBM50508544
Synonyms:
CHEMBL4538989
Type:
Small organic molecule
Emp. Form.:
C28H28N6O2S
Mol. Mass.:
512.626
SMILES:
CN1CCC(C1)NS(=O)(=O)c1ccccc1Nc1cc(-c2ccc3ccn(C)c3c2)c2nccnc2c1
Structure:
Search PDB for entries with ligand similarity: