Reaction Details Report a problem with these data
Target
Cyclic AMP-dependent transcription factor ATF-1
Ligand
BDBM50062645
Substrate
n/a
Meas. Tech.
ChEMBL_27877 (CHEMBL640575)
IC50
120±n/a nM
Citation
Sullivan, RW; Bigam, CG; Erdman, PE; Palanki, MS; Anderson, DW; Goldman, ME; Ransone, LJ; Suto, MJ 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem 41:413-9 (1998) [PubMed] Article
More Info.:
Target
Name:
Cyclic AMP-dependent transcription factor ATF-1
Synonyms:
ATF1 | ATF1_HUMAN | Activating transcription factor 1 | Cyclic AMP-dependent transcription factor ATF-1 | Protein TREB36 | cAMP-dependent transcription factor ATF-1
Type:
PROTEIN
Mol. Mass.:
29236.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_27877
Residue:
271
Sequence:
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
Inhibitor
Name:
BDBM50062645
Synonyms:
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid butyl ester | CHEMBL131636
Type:
Small organic molecule
Emp. Form.:
C18H14ClF6N3O3
Mol. Mass.:
469.765
SMILES:
CCCCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F