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Target
Sterol O-acyltransferase 1
Ligand
BDBM50063231
Substrate
n/a
Meas. Tech.
ChEMBL_28497 (CHEMBL645927)
IC50
12±n/a nM
Citation
 Sliskovic, DR; Picard, JA; O'Brien, PM; Liao, P; Roark, WH; Roth, BD; Anderson, MA; Mueller, SB; Bocan, TM; Bousley, RF; Hamelehle, KL; Homan, R; Reindel, JF; Stanfield, RL; Turluck, D; Krause, BR alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity. J Med Chem 41:682-90 (1998) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50063231
Synonyms:
CHEMBL159621 | N-(2,6-Diisopropyl-phenyl)-2-phenyl-malonamic acid 1,1-dimethyl-tridecyl ester
Type:
Small organic molecule
Emp. Form.:
C36H55NO3
Mol. Mass.:
549.8268
SMILES:
CCCCCCCCCCCCC(C)(C)OC(=O)C(C(=O)Nc1c(cccc1C(C)C)C(C)C)c1ccccc1
Structure:
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