Target
Acid-sensing ion channel 1
Ligand
BDBM50510054
Substrate
n/a
Meas. Tech.
ChEMBL_1839999 (CHEMBL4340214)
IC50
>30000±n/a nM
Citation
 Bencheva, LIDe Matteo, MFerrante, LFerrara, MPrandi, ARandazzo, PRonzoni, SSinisi, RSeneci, PSumma, VGallo, MVeneziano, MCellucci, AMazzocchi, NMenegon, ADi Fabio, R Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS. ACS Med Chem Lett 10:627-632 (2019) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 1
Synonyms:
ASIC1_MOUSE | Accn2 | Acid-sensing ion channel | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | Asic | Asic1 | Bnac2 | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59657.36
Organism:
Mus musculus
Description:
ChEMBL_119368
Residue:
526
Sequence:
MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Inhibitor
Name:
BDBM50510054
Synonyms:
CHEMBL4445209
Type:
Small organic molecule
Emp. Form.:
C17H17FN4
Mol. Mass.:
296.3421
SMILES:
Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cn1
Structure:
Search PDB for entries with ligand similarity: