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Target
V-type proton ATPase subunit S1
Ligand
BDBM50064183
Substrate
n/a
Meas. Tech.
ChEMBL_210943 (CHEMBL812903)
IC50
1900±n/a nM
Citation
 Gagliardi, S; Nadler, G; Consolandi, E; Parini, C; Morvan, M; Legave, MN; Belfiore, P; Zocchetti, A; Clarke, GD; James, I; Nambi, P; Gowen, M; Farina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem 41:1568-73 (1998) [PubMed]  Article 
Target
Name:
V-type proton ATPase subunit S1
Synonyms:
ATP6AP1 | ATP6IP1 | ATP6S1 | Protein XAP-3 | V-ATPase Ac45 subunit | V-ATPase S1 accessory protein | V-ATPase subunit S1 | V-type proton ATPase subunit S1 | VAS1_HUMAN | VATPS1 | Vacuolar ATP synthase subunit S1 | Vacuolar proton pump subunit S1 | XAP3
Type:
PROTEIN
Mol. Mass.:
52022.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_215469
Residue:
470
Sequence:
MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPAADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQVTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCASFFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
  
Inhibitor
Name:
BDBM50064183
Synonyms:
(2E,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid methyl ester | CHEMBL39097
Type:
Small organic molecule
Emp. Form.:
C15H13Cl2NO3
Mol. Mass.:
326.175
SMILES:
COC(=O)C(\OC)=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1
Structure:
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