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TargetVacuolar ATP synthase subunit S1
LigandBDBM50064186
Substrate/Competitorn/a
Meas. Tech.ChEMBL_210944
IC50 100±n/a nM
Citation Gagliardi, SNadler, GConsolandi, EParini, CMorvan, MLegave, MNBelfiore, PZocchetti, AClarke, GDJames, INambi, PGowen, MFarina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem41:1568-73 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vacuolar ATP synthase subunit S1
Name:Vacuolar ATP synthase subunit S1
Synonyms:Protein XAP-3 | V-ATPase Ac45 subunit | V-ATPase S1 accessory protein | V-ATPase subunit S1 | V-type proton ATPase subunit S1 | Vacuolar proton pump subunit S1
Type:PROTEIN
Mol. Mass.:52022.67
Organism:Homo sapiens (Human)
Description:ChEMBL_215469
Residue:470
Sequence:
MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPA
ADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNL
ENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIR
LPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGL
GRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGS
FWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQ
VTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCAS
FFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50064186
NameBDBM50064186
Synonyms:(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one | CHEMBL290814 | bafilomycin A1
TypeSmall organic molecule
Emp. Form.C35H58O9
Mol. Mass.622.8296
SMILESCO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C |c:5,15,18,t:3|
Structure
n/a